Chromosome aberrations in prophylactic mastectomies from women belonging to breast cancer families
✍ Scribed by Catarina Petersson; Nikos Pandis; Fredrik Mertens; Adewale Adeyinka; Christian Ingvar; Anita Ringberg; Ingrid Idvall; Lennart Bondeson; Åke Borg; Håkan Olsson; Ulf Kristoffersson; Felix Mitelman
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 419 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1045-2257
No coin nor oath required. For personal study only.
✦ Synopsis
Short-term cultures of samples from eight prophylactic mastectomies from five unrelated women who were genetically predisposed to breast cancer were analyzed cytogenetically. Clonal chromosome abnormalities were detected in five breasts.
Three samples from two women had aberrations involving the short arm of chromosome 3, with a breakpoint in 3p I4 in common. Three samples from three women had rearrangements of I q. Two of them, one of which also displayed a 3p I4 rearrangement, shared a breakpoint in I94 I. Both I q4 I and, in particular, 3p 14 have been reported to be rearranged frequently in malignant breast proliferations. Whether alterations of genes in these bands are essential in mammary wmorigenesis and, if so. whether they are equally important in sporadic and in hereditary cases remains to be explored.