Chromosome aberrations in 450 sperm complements from eight controls and lack of increase after chemotherapy in two patients
✍ Scribed by J. Jenderny; M. L. Jacobi; A. Rüger; G. Röhrborn
- Publisher
- Springer
- Year
- 1992
- Tongue
- English
- Weight
- 299 KB
- Volume
- 90
- Category
- Article
- ISSN
- 0340-6717
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✦ Synopsis
Four hundred fifty sperm complements from eight controls were analyzed. A conservative estimate of aneuploidy was 1.8% with a hyperhaploid rate of 0.9% (4/450). The overall frequency of structural aberrations was 8.9% (40/450). The proportion of X-bearing (47.5%) and Y-bearing (52.5%) sperm did not differ significantly. Sperm complements were analyzed from a cancer patient 9 months after polychemotherapy (n = 63) and from a patient being treated with Imurek (azathioprine) (n = 30). There was no significant increase in the incidence of numerical and structural chromosome aberrations in the sperm of either patient. The percentages of X-bearing and Y-bearing sperm were not significantly different from the expected 50%.