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Chromosome 9p21 gene copy number and prognostic significance of p16 in ESFT

✍ Scribed by Brownhill, S C; Taylor, C; Burchill, S A

Book ID
109999181
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
282 KB
Volume
96
Category
Article
ISSN
0007-0920

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## Abstract The __p16__^INK4a^ gene, localized within chromosome 9p21, has been identified as a cyclin‐dependent kinase inhibitor and may negatively regulate the cell cycle acting as a tumor suppressor. Genetic alterations involving the 9p21 region are common in human cancers. A consecutive series