Chromosome 3p alterations in pancreatic endocrine neoplasia
β Scribed by Eliana Amato; Stefano Barbi; Giorgio Malpeli; Samantha Bersani; Giuseppe Pelosi; Paola Capelli; Aldo Scarpa
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 136 KB
- Volume
- 458
- Category
- Article
- ISSN
- 1432-2307
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Pancreatic endocrine tumors occur sporadically and as part of the multiple endocrine neoplasia type 1 (MEN 1) and von Hippel-Lindau (VHL) syndromes. The MEN1 locus on 11q13 and a candidate tumor suppressor locus on 3p are known to be hemi-or homozygously mutated in a subset of these tumors. Chromoso
## Abstract We have investigated the status of sex chromosomes in 40 pancreatic endocrine tumors (PETs) using 2 complementary techniques: microsatellite and interphase FISH analysis. Twentyβfive tumors were from female and 15 from male patients and included 31 nonfunctioning and 9 functioning PET (
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