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Chromosome 1p21 deletion is a novel prognostic marker in patients with multiple myeloma

✍ Scribed by Hong Chang; Yi Ning; Xiaoying Qi; Joanna Yeung; Wei Xu


Book ID
108675373
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
484 KB
Volume
139
Category
Article
ISSN
0007-1048

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## Abstract Chromosomal region 18q21 is frequently deleted in colorectal cancer (CRC) and is associated with poor prognosis. Potential tumor suppressor mechanisms altered by 18q21 deletion include mediation of TGFΞ² signaling by SMADs. Following the definition of __SMAD4__ deletion as a negative pre