## Abstract Although prostate cancer is still the most diagnosed cancer in men, most genes implicated in its progression are yet to be identified. Chromosome abnormalities have been detected in human prostate tumors, many of them associated with prostate cancer progression. Indeed, alterations (inc
Chromosome 18 suppresses the tumorigenicity of prostate cancer cells
β Scribed by Susan S. Padalecki; Teresa L. Johnson-Pais; Ann M. Killary; Robin J. Leach
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 167 KB
- Volume
- 30
- Category
- Article
- ISSN
- 1045-2257
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Presumptive tumor suppressor genes may be localized to specific chromosomes by the procedure of microcell fusion, whereby individual chromosomes derived from normal human cells are introduced into tumor cells. Allelic loss on chromosome I 8 is commonly seen in endometrial carcinoma, and the DCC gene
## Abstract Previously we immortalized human, nontransformed prostate epithelial cells with SV40 large Tβantigen (SV40TAg) and derived increasingly aggressive sublines from the immortalized line. The progression of the tumorigenic sublines to metastatic capacity was accompanied by the formation of
## Abstract The loss of the Y chromosome is a frequent numerical chromosomal abnormality observed in human prostate cancer. In cancer, loss of specific genetic material frequently accompanies simultaneous inactivation of tumor suppressor genes. It is not known whether the Y chromosome harbors such
## Background: In previous reports, we used microcell fusion-mediated chromosomal transfer to introduce normal human chromosomes into highly metastatic rat prostatic cancer cells to map the location of tumor and metastasis suppressor genes. the gene for prostate-specific antigen as well as several
## Abstract Metaphase comparative genomic hybridisation (CGH) studies indicate that chromosomes 4, 5, 6, 13, 14, 15 and 18 are frequently deleted in primary ovarian cancers (OCs). Therefore we used microcellβmediated chromosome transfer (MMCT) to establish the functional effects of transferring nor