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Chromosome 13 instability and esterase D expression in an osteosarcoma cell line

✍ Scribed by Eivind Hovig; Jan-Olof Winberg; Øystein Fodstad; Anton Brøgger; Tobias Gedde-Dahl


Book ID
119103487
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
392 KB
Volume
24
Category
Article
ISSN
0165-4608

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Using clonal cell cultures, a significant increase in chromosomal aberrations (aneuplolidy, dicentrics and chromatid breaks) were observed in MCF‐7 cells compared with HeLa. BRCA1 expression was lower in MCF‐7 cells than in HeLa cells. Since BRCA1 is known to play a role in the maintenance of chromo