Chromosomal localization of the murine cadherin-11
β Scribed by I. Hoffman; R. Balling
- Publisher
- Springer-Verlag
- Year
- 1995
- Tongue
- English
- Weight
- 115 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0938-8990
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β¦ Synopsis
Molecular reagents: A 481-bp HindIII-fragment from the 3'untranslated region of the cadherin-ll (3170 bp-3651 bp) was used as a hybridization probe.
Allele detection: RFLP analysis of a BglII polymorphism. The 4.7-kb band and the 7.2-kb band correspond to restriction fragment length variants of cadherin-ll gene (Fig. 1).
π SIMILAR VOLUMES
Proteins of the cadherin family regulate cellular adhesion and motility and are believed to act as tumour suppressors. Previous studies have identified frequent mutation and allelic inactivation of the E-cadherin (cadherin-1) locus in diffuse gastric cancer. At least two other cadherin genes, P-cadh