Chromosomal localization and molecular organization of the human genomic fragment containing the TNF/LT locus in transgenic mice

Genomic organization and chromosomal loc

Genomic organization and chromosomal localization of the human CUL2 gene and the role of von Hippel-Lindau tumor suppressor-binding protein (CUL2 and VBP1) mutation and loss in renal-cell carcinoma development

✍ Steven C. Clifford; Sally Walsh; Katie Hewson; Elaine K. Green; Astrid Brinke; P 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 134 KB 👁 2 views

Germline mutations in the von Hippel-Lindau (VHL) disease tumor suppressor gene (TSG) convey a high risk of clear-cell renal-cell carcinoma (CC-RCC) and most sporadic CC-RCCs demonstrate somatic inactivation of the VHL TSG. However, the existence of further CC-RCC gatekeeper genes is implied by CC-R