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Chromosomal instability in human mesenchymal stem cells immortalized with human papilloma virus E6, E7, and hTERT genes

✍ Scribed by Masao Takeuchi; Kikuko Takeuchi; Arihiro Kohara; Motonobu Satoh; Setsuko Shioda; Yutaka Ozawa; Azusa Ohtani; Keiko Morita; Takashi Hirano; Masanori Terai; Akihiro Umezawa; Hiroshi Mizusawa

Publisher
Society for In Vitro Biology
Year
2007
Tongue
English
Weight
486 KB
Volume
43
Category
Article
ISSN
1475-2689

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✍ Shih-Chieh Hung; Den-Mei Yang; Ching-Fang Chang; Ruey-Jen Lin; Jih-Shiuan Wang; πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 French βš– 241 KB

## Abstract hMSCs derived from bone marrow are useful as a species‐specific cell culture system for studying cell lineage differentiation and tissue remodeling. However, hMSCs usually have a short __in vitro__ life span due to replicative senescence. We therefore used a high dose of retroviral vect