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Chromosomal evidence for the transplantability of the shay chloroleukemia

โœ Scribed by M. J. Derelanko; A. S. Moorthy; J. Lobue; R. C. Meagher; A. S. Gordon; J. Mitra; T. N. Fredrickson

Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
358 KB
Volume
10
Category
Article
ISSN
0022-4790

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โœฆ Synopsis

Chloroma cells, which were shown to contain the X and Y chromosomes, were used to induce Shay chloroleukemia (SCL) in female recipients. Karyotype analyses of leukemic myeloblasts which appeared in the peripheral blood of the female recipients during blast crisis demonstrated invariably the presence of the X and Y chromosomes. These results directly demonstrate that transmission of SCL is the result of donor cell colonization and therefore SCL can be considered a true transplantable leukemia. Reports by other workers of viral association with this dissease are discussed in light of our results.

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โœ M. J. Derelanko; J. A. Khouri; Professor J. Lobue; A. S. Gordon ๐Ÿ“‚ Article ๐Ÿ“… 1980 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 638 KB

## Abstract The pathogenesis of anemia of the Shay chloroleukemia (SCL) was studied in rats following SC, IP and IV inoculation of chloroma cells. Little difference in survival was noted regardless of the route of inoculation. A decrease in hematocrit occurred in all SCL rats during approximately t