Chromosomal deletions in anaplastic meningiomas suggest multiple regions outside chromosome 22 as important in tumor progression
✍ Scribed by Annika Lindblom; Martin Ruttledge; V. Peter Collins; Magnus Nordenskjöld; Jan P. Dumanski
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- French
- Weight
- 628 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Meningioma is a common, usually benign, sporadic and solitary tumor of the meninges covering the central nervous system. Meningiomas can become malignant, and such anaplastic tumors are associated with a high rate of recurrence and death from the disease. We analyzed I6 sporadic, anaplastic meningiomas for loss of alleles on the majority of chromosomal arms, in order to define regions in the genome which may be important for tumor progression. Loss of genetic material was observed on all but 2 chromosomes studied. While loss o f heterozygozity (LOH) from chromosome 22 was the most frequent finding, LOH from the short arm of chromosome I was the second most common lesion occurring preferentially in tumors from men, and at a frequency almost as high as for LOH on chromosome 22. This suggests the existence of a tumorsuppressor locus on I p involved in meningioma carcinogenesis.
Three tumor samples from one large, anaplastic tumor, each with distinct histopathological characteristics, were studied. All 3 samples showed deletions on 22q and I p. However, only one tumor sample, with the most malignant histopathological phenotype, displayed, in addition to 22q and I p, deletions on 9q and 17p. This case suggests that the latter 2 chromosomal regions may harbor genes which contribute to the progression of meningioma.