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Chromosomal assignment of two putative canine keratin gene clusters

✍ Scribed by R. C. Keller; M. Switonski; H. Jörg; D. Ladon; S. Arnold; C. Schelling

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
69 KB
Volume
29
Category
Article
ISSN
0268-9146

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✦ Synopsis

Mutations in keratin genes account for a number of inherited keratodermas in humans. The groups of basic and acidic keratin genes are clustered on human chromosomes 12 and 17, respectively. The present authors have assigned the two putative keratin gene clusters to canine chromosomes using canine cosmid clones. Successful fluorescence in situ hybridization mapped the putative cluster of canine acidic genes to dog chromosome 20 and the putative cluster of basic keratin genes to a small autosome not yet included in the partial canine standard karyotype.

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