Chromosomal aberrations in a consecutive series of childhood rhabdomyosarcoma

✍ Scribed by Kullendorff, C.M.; Donner, M.; Mertens, F.; Mandahl, N.

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 27 KB
• Volume: 30
• Category: Article
• ISSN: 0098-1532
• DOI: 10.1002/(sici)1096-911x(199803)30:3<156::aid-mpo5>3.0.co;2-g

✦ Synopsis

Background and procedure:

During a 13-year period, 22 children were treated for rhabdomyosarcoma (rms). in 18 of these patients chromosome analysis was attempted on material from tumor biopsies, fine needle aspiration biopsies and/or bone marrow samples.

Results:

Clonal chromosome aberrations were detected in 14 cases; 7 of 9 embryonal rms, 6 of 8 alveolar rms and in the single case of pleomorphic rms cytogenetic failures were more frequent in fine needle aspiration biopsies than in tumor biopsies. the characteristic t(2;13) translocation was seen in 2 alveolar rms but not in any of the other subtypes. in 3 of the embryonal rms hyperdiploid or hypertetraploid karyotypes with few or no structural rearrangements were seen. in all 3 cases the clinical course was relatively benign, suggesting that certain karyotypic patterns in rms may be of prognostic significance.

Conclusions:

Our results add to the evidence that cytogenetic analysis should be an integral part of the diagnostic examinations of children with rms.