Chromosomal aberrations defining uveal melanoma of poor prognosis
β Scribed by Prescher, G; Bornfeld, N; Horsthemke, B; Becher, R
- Book ID
- 122916485
- Publisher
- The Lancet
- Year
- 1992
- Tongue
- English
- Weight
- 311 KB
- Volume
- 339
- Category
- Article
- ISSN
- 0140-6736
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Background: The clinical course of uveal melanoma differs greatly from that of cutaneous melanoma. Methods: Twenty-four patients with metastatic uveal melanoma (13 men and 11 women; median age at diagnosis, 56 years [range, 17-67 years]) were evaluated retrospectively. Results: Main sites of metas
Posterior uveal melanomas have nonrandom alterations affecting chromosomes 3, 6, and 8. Loss of chromosome 3 in uveal melanoma has been shown to act as a predictor of disease-free and overall survival. To confirm the significance of chromosome 3 loss and to extend the observations to include those o