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Chromosomal 20q gain in the DNA diploid component of aneuploid colorectal carcinomas

✍ Scribed by Paula M. De Angelis; Trond Stokke; Marzieh Beigi; Gøril Flatberg; Marianne Enger; Kristiane Haug; Hans Christian D. Aass; Aasa Schjølberg; Per Arne Andresen; Sarah Ariansen; Anne Signe Bø; Odd Mjåland; Ole Petter Clausen

Publisher: John Wiley and Sons
Year: 2007
Tongue: French
Weight: 183 KB
Volume: 120
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.22537

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✦ Synopsis

Abstract

The order of appearance of different genetic aberrations during the shift from diploidy/near‐diploidy to aneuploidy in colorectal cancers is not yet clear. We studied genetic alterations in flow cytometrically‐sorted DNA diploid and corresponding aneuploid epithelial cell populations from each of 20 colorectal tumors using comparative genomic hybridization, FISH, and PCR. Analysis of the 19 cases in which aberrations were found in the flow‐sorted diploid population indicated that large‐scale aneuploidization in colorectal cancer was preceded by amplification of oncogene(s) localized to chromosome 20q13.2 and by KRAS mutations, but not by TP53 deletions or losses of large chromosomal regions such as 4q, 8p and 18q. © 2007 Wiley‐Liss, Inc.

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