Chromatographic studies on the binding, action and metabolism of (−)-deprenyl

✍ Scribed by Huba Kalász; László Kerecsen; József Knoll; József Pucsok

• Book ID: 104144989
• Publisher: Elsevier Science
• Year: 1990
• Tongue: English
• Weight: 660 KB
• Volume: 499
• Category: Article
• ISSN: 1873-3778
• DOI: 10.1016/s0021-9673(00)97003-1

✦ Synopsis

Serum binding, the effect on striatal dopamine release and the metabolism of (-)-deprenyl

[N-methyl-N-propargy1(2-phenyl-1-methyl)ethylammonium chloride], TZ-650 [N-methyl-N-propargy1(2-phenyl)ethylammonium chloride] and J-508 [Nmethyl-N-propargyl(indanyl)ammonium chloride] were investigated using various chromatographic methods. A strong interaction between ( -)-deprenyl and macroglobulins was found. Deprenyl enhanced the dopamine release from striatal slices of the rat brain and also inhibited the dopamine-DOPAC conversion.

Deprenyl analogues showed either smaller or no effect. Hydroxylation of (-)-deprenyl takes place in the para position, in addition to the usual oxidative N-dealkylations, which are known from various metabolic studies on N-substituted phenylalkylamines.