Chromatographic separation of the 1-methoxy-2(3)-hydroxy-3(2)-bromocyclohexanes and their derivatives

✍ Scribed by A.A. Casselman; R.A.B. Bannard

• Book ID: 104146537
• Publisher: Elsevier Science
• Year: 1965
• Tongue: English
• Weight: 469 KB
• Volume: 20
• Category: Article
• ISSN: 1873-3778
• DOI: 10.1016/s0021-9673(01)97442-4

✦ Synopsis

NOTES

its'diacetate (10 O/~ Versamid-goo) , or a bromodiol and the corresponding cyclohexanediol (10 y0 Versamid-goo). The best separation of, the cis-and tYamTI,2-, and z,3cyclohexanediols was obtained when 30 o/o XFrr50 was used. Finally, the complete separation of @-methoxy-2a,8a-epoxycyclohexane from Ia-methoxy-2a,8c+epoxycyclohexane, was readily effected using the 30 o/o XFrr50 cyanosilicone substrate. Separation of these isomers by fractional distillation is waczco, on the other hand, always gave appreciable quantities of fractions which contain both of the epoxides,