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Chromatographic Separation of Diastereomeric Schiff Base Copper(II), Nickel(II), and Zinc(II) Chelates from α-Amino Acid Racemates

✍ Scribed by Eiko Toyota; Kunihiko Itoh; Haruo Sekizaki; Kazutaka Tanizawa

Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
159 KB
Volume
24
Category
Article
ISSN
0045-2068

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✦ Synopsis

Chromatographic separation of diastereomeric Schiff base copper(II), nickel(II), and zinc(II) chelates derived from optically active 3-substituted salicylaldehyde derivative and Ͱamino acids on a reverse-phase column was found to be successful. The separation of two elution peaks within a pair of enantiomers was excellent for most neutral amino acids. Optically pure Ͱ-amino acids were isolated from the chelates by the addition of EDTA и 2Na. The formation of bis(Schiff base)metal chelates with nickel(II) or zinc(II) was discussed.

📜 SIMILAR VOLUMES

Derivation of Diastereomeric Schiff-Base
Derivation of Diastereomeric Schiff-Base Copper-Chelates from α-Amino-Acid Racemates and Their Chromatographic Separation
✍ K. Tanizawa; Y. Ichikawa; E. Toyota; H. Chinen; Y. Kanaoka 📂 Article 📅 1994 🏛 Elsevier Science 🌐 English ⚖ 279 KB

Salicylaldehyde and pyridoxal derivatives carrying optically active residue were applied for the derivation of Schiff base copper chelates from \(\alpha\)-amino acids. In aqueous media the chelate formation process proceeded spontaneously and the process was reversed by the addition of EDTA. Thus th