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Chromatographic purification of human α1 proteinase inhibitor from dissolved Cohn fraction IV-1 paste

✍ Scribed by Sharon X Chen; David J Hammond; Anthony M Klos; Woody D Wood; James E Wydick; Wytold R Lebing

Book ID: 108341306
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 401 KB
Volume: 800
Category: Article
ISSN: 1873-3778
DOI: 10.1016/s0021-9673(97)01119-9

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## Abstract Human alpha one proteinase inhibitor (α1‐PI) was cloned and expressed in __Aspergillus niger__, filamentious fungus that can grow in defined media and can perform glycosylation. Submerged culture conditions were established using starch as carbon source, 30% dissolved oxygen concentrati