The introduction of a lipophilic moiety into the gadolinium chelate Gd-DTPA (dimeglumine gadopentetate, Magnevist) yielded Gd-EOB-DTPA (short form), which has potential as a magnetic resonance contrast agent for liver mass screening. The pharmacokinetics of Gd-EOB-DTPA in rats is nonlinear because a
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Chromatographic methods for the quantification of free and chelated gadolinium species in MRI contrast agent formulations
โ Scribed by Danielle Cleveland; Stephen E. Long; Lane C. Sander; W. Clay Davis; Karen E. Murphy; Ryan J. Case; Catherine A. Rimmer; Lorena Francini; Anil K. Patri
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 229 KB
- Volume
- 398
- Category
- Article
- ISSN
- 1618-2650
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A rapid, stability-indicating, reversed-phase high-performance liquid chromatographic method for the direct and simultaneous determination of a new /I-lactam molecule and its salt-forming agent in finished dosage forms was studied for the development of injectable formulations.