Chromatographic evaluation of chiral (1R-trans)-N, N′ -1,2-cyclohexylenebisbenzamide-oligodimethylsiloxane copolymeric stationary phases for capillary supercritical fluid chromatography

✍ Scribed by Patrik Petersson; Karin E. Markides; Deborah F. Johnson; Bryant E. Rossiter; Jerald S. Bradshaw; Milton L. Lee

• Book ID: 102944492
• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 542 KB
• Volume: 4
• Category: Article
• ISSN: 1040-7685
• DOI: 10.1002/mcs.1220040207

✦ Synopsis

Abstract

A novel approach to the design of chiral stationary phases (CSPs) is illustrated by the synthesis and evaluation of selective and efficient copolymeric CSPs with alternating chiral (1__R‐trans__)‐N, N′‐1,2‐cyclohexylenebisbenzamide and achiral (oligodimethylsiloxane) blocks. These materials are shown to resolve a variety of chiral diols. Evaluation of the performance of one of these phases in GC and SFC suggests that SFC can produce higher resolution because of its lower operating temperature which facilitates solute‐stationary phase interactions. The influence of different chiral (position of substitution) and achiral (chain length) blocks of the copolymer on solute retention, efficiency, chiral selectivity, and resolution were studied, as well as the reproducibility of the column preparation method.