Chromatin Regulation and Dynamics

✍ Scribed by Anita Göndör

• Publisher: Academic Press
• Year: 2016
• Tongue: English
• Leaves: 475
• Edition: 1
• Category: Library

✦ Synopsis

Chromatin Regulation and Dynamics integrates knowledge on the dynamic regulation of primary chromatin fiber with the 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes. The final chapters discuss the many ways chromatin dynamics can synergize to fundamentally contribute to the development of complex diseases.

Chromatin dynamics, which is strategically positioned at the gene-environment interface, is at the core of disease development. As such, Chromatin Regulation and Dynamics, part of the Translational Epigenetics series, facilitates the flow of information between research areas such as chromatin regulation, developmental biology, and epidemiology by focusing on recent findings of the fast-moving field of chromatin regulation.

• Presents and discusses novel principles of chromatin regulation and dynamics with a cross-disciplinary perspective
• Promotes crosstalk between basic sciences and their applications in medicine
• Provides a framework for future studies on complex diseases by integrating various aspects of chromatin biology with cellular metabolic states, with an emphasis on the dynamic nature of chromatin and stochastic principles
• Integrates knowledge on the dynamic regulation of primary chromatin fiber with 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes

✦ Table of Contents

Content:
Front matter,Copyright,List of Contributors,PrefaceEntitled to full textChapter 1 - A Brief Introduction to Chromatin Regulation and Dynamics, Pages 1-34, I. Tzelepis, M. Martino, A. Göndör
Chapter 2 - Histone Modifications and Histone Variants in Pluripotency and Differentiation, Pages 35-64, A.J. Bannister, A.M. Falcão, G. Castelo-Branco
Chapter 3 - Dynamics and Function of DNA Methylation During Development, Pages 65-94, A. Lennartsson
Chapter 4 - ATP-Dependent Chromatin Remodeling: From Development to Disease, Pages 95-116, M. Lezzerini, C.G. Riedel
Chapter 5 - Chromatin Dynamics During the Cell Cycle, Pages 117-139, D. Doenecke
Chapter 6 - Epigenetic Regulation of Replication and Replication Timing, Pages 141-163, C. Brossas, A-.L. Valton, B. Duriez, M-.N. Prioleau
Chapter 7 - Regulation of Cellular Identity by Polycomb and Trithorax Proteins, Pages 165-189, M. Wassef, R. Margueron
Chapter 8 - Interplay Between Chromatin and Splicing, Pages 191-209, A. Fiszbein, M.A. Godoy Herz, L.I. Gomez Acuña, A.R. Kornblihtt
Chapter 9 - Crosstalk Between Non-Coding RNAs and the Epigenome in Development, Pages 211-234, M. Berdasco, M. Esteller
Chapter 10 - Epigenetic Regulation of Nucleolar Functions, Pages 235-274, A-.K. Östlund Farrants
Chapter 11 - Chromatin Dynamics and DNA Repair, Pages 275-302, P. Agarwal, K.M. Miller
Chapter 12 - Regulation of Centromeric Chromatin, Pages 303-324, D. Bade, S. Erhardt
Chapter 13 - Telomere Maintenance in the Dynamic Nuclear Architecture, Pages 325-352, E. Micheli, A. Galati, A. Cicconi, S. Cacchione
Chapter 14 - Epigenetic Regulation of X-Chromosome Inactivation, Pages 353-371, M.E. Donohoe
Chapter 15 - Interaction Between Cellular Metabolic States and Chromatin Dynamics, Pages 373-398, S.J. Linder, R. Mostoslavsky
Chapter 16 - Circadian Plasticity of Chromatin States, Pages 399-416, W.J. Belden
Chapter 17 - 3D Nuclear Architecture and Epigenetic Memories: Regulators of Phenotypic Plasticity in Development, Aging and Cancer, Pages 417-460, B.A. Scholz, L. Millán-Ariño, A. Göndör
Index, Pages 461-473