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Chromatin dynamics at DNA replication, transcription and repair

✍ Scribed by Ann E. Ehrenhofer-Murray


Book ID
110915084
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
386 KB
Volume
271
Category
Article
ISSN
1432-1327

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During DNA replication, transcription and DNA repair in eukaryotes, the cellular machineries performing these tasks need to gain access to the DNA that is packaged into chromatin in the nucleus. Chromatin is a dynamic structure that modulates the access of regulatory factors to the genetic material.

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## Abstract We have investigated the in situ organization of ribosomal gene (rDNA) transcription and replication in HeLa cells. Fluorescence in situ hybridization (FISH) revealed numerous rDNA foci in the nucleolus. Each rDNA focus corresponds to a higher order chromatin domain containing multiple