The X-linked agammaglobulinaemia (XLA) gene locus has previously been mapped to Xq22 in genetic linkage studies. The DXS101 locus has shown no recombinations with XLA in the ten informative meioses investigated so far. The DXS101 sequence, recognised by the cX52.5 plasmid, is moderately repeated in
Choroideremia-locus maps between DXS3 and DXS11 on Xq
✍ Scribed by A. Gal; F. Brunsmann; D. Hogenkamp; K. Rüther; D. Ahlert; T. F. Wienker; W. Hammerstein; I. H. Pawlowitzki
- Publisher
- Springer
- Year
- 1986
- Tongue
- English
- Weight
- 342 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0340-6717
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X-linked agammaglobulinaemia (XLA) is an inherited disorder characterised by a lack of circulating B-cells and antibodies. While the gene involved in XLA has not yet been identified, the locus for the disorder is tightly linked to the polymorphic marker DXS178, which maps to Xq22. Fabry disease is a
Linkage analysis was performed in 19 families segregating for the Wiskott-Aldrich syndrome (WAS) and in 1 family with X-linked thrombocytopenia using nine polymorphic DNA markers spanning the interval DXS7-DXS14. The results confirm close linkage of WAS to the DXS7, TIMP, OATL1, DXS255, DXS146, and