Chondroitin sulfate proteoglycan with neurite-inhibiting activity is up-regulated following peripheral nerve injury
✍ Scribed by Zuo, Jian ;Hernandez, Yosbani J. ;Muir, David
- Book ID
- 101258330
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 378 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0022-3034
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✦ Synopsis
Numerous findings support the posrounding axon-Schwann cell units and within nodes sibility that highly sulfated proteoglycans are inhibiof Ranvier. Following nerve crush injury, immunolatory molecules which, at high concentration relative beling of CSPG and laminin became more intense in to growth-promoting signals, may regulate or guide distal nerve and CSPG increased within endoneurium axonal growth. Although most studies implicate suland surrounding nerve sheaths. Embryonic dorsal fated proteoglycans in the poor regenerative capacity root ganglionic neurons cultured on longitudinal of the central nervous system, inhibitory proteoglynerve sections extended neurites along the exposed cans also may play an important role in the successful surfaces of Schwann cell basal lamina. The length of regeneration of axons within peripheral nerve. Culneurites was increased 58% on normal nerve sections tured rat schwannoma and Schwann cells produce pretreated with chondroitinase. Even though laminin chondroitin sulfate proteoglycan (CSPG) which binds levels were elevated in basal lamina of injured nerve, to and inhibits the neurite-promoting activity of lamineuritic growth on sections of injured nerve was not nin [Muir et al. (1989) J. Cell Biol. 109:2353]. In the significant increased unless sections were pretreated present study, we found a similar neurite-inhibiting with chondroitinase. These results indicate that inhibiactivity associated with CSPG isolated from normal tory CSPG is up-regulated in injured nerve and plays adult rat sciatic nerve. Following nerve crush injury, a role in regulating axonal regeneration. ᭧ 1998 John this inhibitory activity was increased sevenfold in re-