Chondroitin Sulfate Inhibits the Nuclear Translocation of Nuclear Factor-κB in Interleukin-1β-Stimulated Chondrocytes
✍ Scribed by Claudia Jomphe; Mélanie Gabriac; Taben M. Hale; Lucie Héroux; Louis-Éric Trudeau; Denis Deblois; Eulalia Montell; Josep Vergés; Patrick Du Souich
- Book ID
- 111316411
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 212 KB
- Volume
- 0
- Category
- Article
- ISSN
- 1742-7835
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Objective. To determine how interleukin-1 (IL-1), through activation of collagenase 1 (matrix metalloproteinase 1 [MMP-I]) transcription in synovial fibroblasts, contributes to cartilage degradation in rheumatoid arthritis. Methods. Primary rabbit synovial fibroblasts were transiently transfected w
In infectious diseases of the central nervous system astrocytes respond to inflammatory cytokines like tumor necrosis factor ␣ (TNF␣) by activation of the transcription factor NF-B, mediated by the proteolysis of its inhibitors IB␣ and IB. We studied the kinetics of NF-B induction by TNF␣ in primar
## Abstract IL‐1β is an important mediator in the pathogenesis of type 1 diabetes both in vivo and in vitro and it has been shown to induce islet β‐cell apoptosis. Most of the IL‐1β effects seem to be mediated by NF‐κB transcription factor activation, but its role in the induction of islet β‐cell a