Chondroitin sulfate-binding peptides block chondroitin 6-sulfate inhibition of cortical neurite growth
β Scribed by Karen Chao Butterfield; Aaron Conovaloff; Michael Caplan; Alyssa Panitch
- Book ID
- 116772268
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 576 KB
- Volume
- 478
- Category
- Article
- ISSN
- 0304-3940
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π SIMILAR VOLUMES
## Abstract The central nervous system (CNS) fails to regenerate after injury. A glial scar forms at the injury site, contributing to regenerative failure partly resulting from the chondroitin sulfate proteoglycans (CSPGs) in the glial scar. The family of Rho GTPases, which includes Cdc42, Rac1, an
## Abstract Activation of the Rho kinase (ROCK) pathway has been associated with inhibition of neurite regeneration and outgrowth in spinal cord injury. Growthβinhibitory substances present in the glial scar such as chondroitin sulfate proteoglycans (CSPGs) have been shown to create a nonpermissive