Chondrogenesis, osteogenesis and adipogenesis of canine mesenchymal stem cells: a biochemical, morphological and ultrastructural study
β Scribed by C. Csaki; U. Matis; A. Mobasheri; H. Ye; M. Shakibaei
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 924 KB
- Volume
- 128
- Category
- Article
- ISSN
- 1432-119X
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The molecular mechanisms by which bone morphogenetic proteins (BMPs) promote skeletal cell differentiation were investigated in the murine mesenchymal stem cell line C3H10T1/2. Both BMP-7 and BMP-2 induced C3H10T1/2 cells to undergo a sequential pattern of chondrogenic followed by osteogenic differe
Human aging is associated with a progressive decline in bone mass and an accumulation of marrow fat. We found that osteoblast differentiation was reduced and adipocyte formation increased in bone marrow stromal cells derived from aged mice compared with young controls. The increased adipogenesis cor