β Scribed by Ikemefuna Onyekwelu; Mary B. Goldring; Chisa Hidaka
No coin nor oath required. For personal study only.
The repair of joint surface defects remains a clinical challenge, as articular cartilage has a limited healing response. Despite this, articular cartilage does have the capacity to grow and remodel extensively during preβ and postβnatal development. As such, the elucidation of developmental mechanisms, particularly those in postβnatal animals, may shed valuable light on processes that could be harnessed to develop novel approaches for articular cartilage tissue engineering and/or regeneration to treat injuries or degeneration in adult joints. Much has been learned through mouse genetics regarding the embryonic development of joints. This knowledge, as well as the less extensive available information regarding postβnatal joint development is reviewed here and discussed in relation to their possible relevance to future directions in cartilage tissue repair and regeneration. J. Cell. Biochem. 107: 383β392, 2009. Β© 2009 WileyβLiss, Inc.
π SIMILAR VOLUMES
## Abstract Synovial joints are elegant, critically important, and deceptively simple biomechanical structures. They are comprised of articular cartilage that covers each end of the opposing skeletal elements, synovial fluid that lubricates and nourishes the tissues, ligaments that hold the skeleta
## Abstract The articular cartilage of the incudomalleal joint appears to be secondary or chondroid cartilage, formed and maintained by the synovial cells of the joint space. It might be considered epiphyseal cartilage, forming chondroid cartilage and chondroid bone normally within the deep cartila
## Abstract The purpose of this study was to clarify the effect of gradual weight bearing (GWB) on regenerating cartilage. We developed a novel external fixation device (EFD) with a controllable weightβbearing system and continuous passive motion (CPM). A fullβthickness defect was created by resect