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Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration?

✍ Scribed by P.M. van der Kraan; W.B. van den Berg

Book ID
113733409
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
353 KB
Volume
20
Category
Article
ISSN
1063-4584

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## Abstract We investigated whether __N__‐acetylcysteine (NAC), a precursor of glutathione, could protect rabbit articular chondrocytes against nitric oxide (NO)‐induced apoptosis and could prevent cartilage destruction in an experimental model of osteoarthritis (OA) in rats. Isolated chondrocytes