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Cholinesterase and carboxylesterase inhibition by dichlorvos and interactions with malathion and triorthotolyl phosphate

โœ Scribed by Steven D. Cohen; Marion Ehrich

Book ID
119482737
Publisher
Elsevier Science
Year
1976
Tongue
English
Weight
663 KB
Volume
37
Category
Article
ISSN
0041-008X

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The organophosphorothioate (OPT) pesticide malathion (MAL) in mammals is readily hydrolyzed by mammalian carboxylesterases (CE). The reaction competes with the CYP-catalyzed formation of malaoxon (MOX), the toxic metabolite. Alterations or individual variations in CE activity may result in increased