## Abstract The cerebral deposition of amyloid Ξ²βpeptide, a central event in Alzheimer's disease (AD) pathogenesis, begins several years before the onset of clinical symptoms. Noninvasive detection of AD pathology at this initial stage would facilitate intervention and enhance treatment success. In
Cholinergic neuropathology in a mouse model of Alzheimer's disease
β Scribed by Dwight C. German; Umar Yazdani; Samuel G. Speciale; Parichehr Pasbakhsh; Dora Games; Chang-Lin Liang
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 836 KB
- Volume
- 462
- Category
- Article
- ISSN
- 0021-9967
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## Abstract ## Purpose To demonstrate an MRI method for directly visualizing amyloidβΞ² (AΞ²) plaques in the APP/PS1 transgenic (tg) mouse brain in vivo, and show that T~1Ο~ relaxation rate increases progressively with Alzheimer's disease (AD)βrelated pathology in the tg mouse brain. ## Materials a
Abnormal subgranular zone (SGZ) neurogenesis is proposed to contribute to Alzheimer's disease (AD)-related decreases in hippocampal function. Our goal was to examine hippocampal neurogenesis in the PDAPP mouse, a model of AD with age-dependent accumulation of amyloid-β€ 42 (Aβ€ 42 )-containing plaques