𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Cholinergic modulation of memory in rats

✍ Scribed by Vahram Haroutunian; Edward Barnes; Kenneth L. Davis

Publisher
Springer
Year
1985
Tongue
English
Weight
667 KB
Volume
87
Category
Article
ISSN
0033-3158

No coin nor oath required. For personal study only.

✦ Synopsis

Central cholinergic systems have long been implicated in the modulation of learning and memory processes in animals and man. Drugs that affect the central cholinergic system have been found either to enhance or to hinder performance in tests of learning and memory. Few studies have evaluated the effects of different cholinergic drugs within a single experimental paradigm and with a relatively wide dose range. The studies reported here investigated the effects of cholinergic drugs with diverse modes of action on the retention of a passive avoidance response. Physostigmine, arecoline, oxotremorine, nicotine, and 4-aminopyridine were administered IP immediately following the acquisition of a one-trial passive avoidance task. All of the drugs were found to enhance 72-h retention of passive avoidance; however, the effective doses were different for each of the drugs studied.

πŸ“œ SIMILAR VOLUMES

Modulation of memory by post-training ep
Modulation of memory by post-training epinephrine: involvement of cholinergic mechanisms
✍ Ines B. Introini-Collison; James L. McGaugh πŸ“‚ Article πŸ“… 1988 πŸ› Springer 🌐 English βš– 775 KB

Extensive evidence indicates that memory storage can be modulated by peripheral epinephrine as well as by drugs affecting the muscarinic cholinergic system. Low doses of epinephrine (Epi) facilitate memory while high doses induce amnesia. Retention is enhanced by post-training administration of chol

Modulation of social memory in male rats
Modulation of social memory in male rats by neurohypophyseal peptides
✍ R. Dantzer; R. -M. Bluthe; G. F. Koob; M. Moal πŸ“‚ Article πŸ“… 1987 πŸ› Springer 🌐 English βš– 598 KB

Adult male rats spend a great amount of time investigating novel juveniles. In contrast, rats re-exposed to the same juvenile 30 rain after the initial exposure display little investigatory behavior. If the re-exposure occurs 2 h later, the juvenile is thoroughly investigated. These results have bee