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Cholinergic-dopaminergic interactions and the mechanisms of action of antidepressants

✍ Scribed by Mathew T. Martin-Iverson; Jean-Francois Leclere; Hans C. Fibiger

Book ID
115877966
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
765 KB
Volume
94
Category
Article
ISSN
0014-2999

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Bromocriptine (BRC), a dopamine D-2 receptor agonist, physostigmine, an anticholinesterase agent and pilocarpine, a muscarinic cholinergic receptor agonist, produced yawning in rats, with the most effective doses being 2.5 mg/kg, 0.2 mg/kg and 4 mg/kg, respectively. BRC-induced yawning was inhibited