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Cholinergic- and stress-induced signaling activities in cells overexpressing wild-type and mutant presenilin-1

✍ Scribed by Patrizia De Sarno; Mathieu Lesort; Gautam N Bijur; Gail V.W Johnson; Richard S Jope

Book ID
113997136
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
387 KB
Volume
903
Category
Article
ISSN
0006-8993

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## Abstract The majority of early‐onset familial Alzheimer disease cases are caused by mutations in the genes encoding presenilin 1 (PS1) and presenilin 2 (PS2). Presenilin mutations have been hypothesised to cause Alzheimer disease either by altering amyloid precursor protein metabolism or by incr