## Abstract Recent studies indicate that trkA expression is reduced in endβstage Alzheimer's disease (AD). However, understanding the neuropathologic correlates of early cognitive decline, as well as the changes that underlie the transition from nondemented mild cognitive impairment (MCI) to AD, ar
Cholinergic and neurotrophic markers within the nucleus basalis in elderly individuals with mild cognitive impairment and early Alzheimer's disease
β Scribed by Mufson, Elliott J.; Ma, Shuang Y.; Gilmor, Michele L.; Bennett, David A.; Beckett, Laurel A.; Cochran, Elizabeth J.; Levey, Alan I.; Kordower, Jeffrey H.
- Book ID
- 122875051
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 363 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0197-4580
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π SIMILAR VOLUMES
Recent studies indicate that there is a marked reduction in trkA-containing nucleus basalis neurons in end-stage Alzheimer's disease (AD). We used unbiased stereological counting procedures to determine whether these changes extend to individuals with mild cognitive impairment (MCI) without dementia
Immunocytochemistry for choline acetyltransferase (ChAT) and the vesicular acetylcholine transporter (VAChT) was used to examine the expression of these linked cholinergic markers in human basal forebrain, including cases with early stages of Alzheimer's disease (AD). Previous neurochemical studies