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Cholinergic agonists increase intracellular Ca2+ in cultured human microglia

✍ Scribed by Lili Zhang; James G McLarnon; Vikram Goghari; Yong Beom Lee; Seung U Kim; Charles Krieger

Book ID
117477093
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
48 KB
Volume
255
Category
Article
ISSN
0304-3940

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A synthetic peptide consisting of amino acid residues 106 to 126 of the human prion protein (PrP c ) that forms fibrils in vitro is toxic to cultured neurons. We have previously shown that the neurotoxic effect of this peptide is related to microglia activation (Brown et al., 1996a). For closer insi