Cholinergic activation of the lobster cardiac ganglion
โ Scribed by Sullivan, Robert E. ;Miller, Mark W.
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 919 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0022-3034
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โฆ Synopsis
The frequency of rhythmic burst activity of the isolated lobster cardiac ganglion is increased by exogenously applied acetylcholine and muscarinic agonists. Responses of individual motor neurons isolated from the ganglion by transection consist of a slow depolarization and repetitive bursting. The pharmacological profile of the receptors mediating this response is similar to that of verte-brate neuronal muscarinic receptors. Isolated ganglia incubated in the presence of I3Hj-choline (18-19 h) exhibited radiolabelled acetylcholine accumulation. It is suggested that ganglionic excitation may be accomplished by extrinsic or intrinsic activation of muscarinic receptors on the motor neurons.
๐ SIMILAR VOLUMES
Impulse activity of the bursting neurones in the intact or segmented cardiac ganglion could be recorded in the isolated and freely beating hearts of lobsters. In the segmented ganglion, the four large cells (LCs), the medium cell (MC), and the four small cells (SCs) generated phasic, short tonic, an