Choline levels, the regulation of acetylcholine and phosphatidylcholine synthesis, and Alzheimer's disease
β Scribed by R. J. Wurtman; I. H. Ulus; J. K. Blusztajn; I. Lopez-Coviella; J. Agut; J. A. Ortiz; M. Logue; C. Mauron; J. H. Growdon
- Publisher
- Springer
- Year
- 1989
- Tongue
- English
- Weight
- 72 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1435-1463
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Immunocytochemistry for choline acetyltransferase (ChAT) and the vesicular acetylcholine transporter (VAChT) was used to examine the expression of these linked cholinergic markers in human basal forebrain, including cases with early stages of Alzheimer's disease (AD). Previous neurochemical studies
The metabolism of choline by rat brain, plasma, and liver was investigated using combined gas chromatography mass spectrometry following microwave irradiation and treatment with deuterium-labeled choline. Methods were established to measure simultaneously the concentrations of six choline-containing