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Choline acetyltransferase immunoreactivity in the human vestibular end-organs

✍ Scribed by Akira Ishiyama; Ivan Lopez; Phillip A. Wackym

Publisher: Elsevier Science
Year: 1994
Tongue: English
Weight: 391 KB
Volume: 18
Category: Article
ISSN: 1065-6995
DOI: 10.1006/cbir.1994.1019

No coin nor oath required. For personal study only.

✦ Synopsis

ABSTRACT

Acetylcholine (ACh) is believed to play a major role in the efferent vestibular system in several animal models, however no information regarding the role of ACh in the human efferent vestibular system has been published. Post‐embedding immunohistochemistry in a hydrophilic resin was used to investigate the choline acetyltransferase immunoreactivity (ChATi) and acetylcholinesterase (ACHE) histochemistry in human vestibular end‐organs. ChATi and AChE activity was found in numerous bouton‐type terminals at the basal area of the vestibular hair cells. These terminals were found to contact type II vestibular hair cells and the afferent chalices surrounding type I hair cells. This study provides the first evidence that the human efferent vestibular axons and terminals are cholinergic.

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