𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Cholesterol of myelin is the determinant of gray-white contrast in MRI of brain

✍ Scribed by Seymour H. Koenig

Book ID
102530707
Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
468 KB
Volume
20
Category
Article
ISSN
0740-3194

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The relative brightness of adult white matter in T~1~‐weighted MRI arises from myelin, but the mechanisms responsible remain to be clarified. Koenig et al. [Magn. Reson. Med. 14, 482 (1990)] conjectured that the cholesterol of myelin (∼ 30% of its lipid) was responsible. We present 1/T~1~ and magnetization transfer contrast imaging data [Wolff and Balaban, Magn. Reson. Med. 10, 135 (1989)] on a model system— 50% lipid—50% water by weight, with the lipid one‐half phosphatidyl cholinc (PC) and one‐half cholesterol—and a control in which the lipid is all PC. The differences between the model and control samples mimic the myelin contribution to white matter in both experiments. © 1991 Academic Press, Inc.

📜 SIMILAR VOLUMES

Total brain white matter is a major dete
Total brain white matter is a major determinant of IQ in adolescents born preterm
✍ Gemma B. Northam; Frédérique Liégeois; Wui K. Chong; John S. Wyatt; Torsten Bald 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 291 KB

## Abstract ## Objective In preterm infants, white matter (WM) abnormalities detected on magnetic resonance imaging (MRI) at term‐age are associated with early developmental delay. We set out to study this association in adolescents born pre‐term, by examining intellectual outcome in relation to m