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Cholesterol domains in cationic lipid/DNA complexes improve transfection

โœ Scribed by Long Xu; Thomas J. Anchordoquy


Book ID
116274653
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
370 KB
Volume
1778
Category
Article
ISSN
0005-2736

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## Abstract ## Background Over the last several years, we have developed a novel class of cationic lipids, cholesterol derivatives characterized by polar head groups with guanidinium functions. We have in particular shown that bis(guanidinium)โ€trenโ€cholesterol/dioleoylphosphatidylethanolamine (BGT