Cholesterol and pigment gallstones in Northern India
β Scribed by Shiv K. Sarin; Brij M. L. Kapur; Rakesh K. Tandon
- Book ID
- 112510073
- Publisher
- Springer US
- Year
- 1986
- Tongue
- English
- Weight
- 539 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0163-2116
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Female Hartley guinea pigs fed a 0.5% cholesterol-supplemented diet were found to form pigmented gallstones after 6 weeks (17/23) and 12 weeks (1 1/1 l), while only 2 of 44 animals fed a trace cholesterol diet formed gallstones over a comparable period. The light brown stones consisted primarily of
We have previously isolated from 13 cholesterol gallstones a low molecular weight acidic bili-protein that inhibited the precipitation of calcium carbonate in uitro. We now report the isolation of a similar protein from seven black pigment gallstones. Cholesterol was removed from the stones by Soxhl
Calcium bilirubinate, palmitate, carbonate and phosphate have been identified in the cores of cholesterol and pigment gallstones, suggesting a role for precipitated calcium salts in the early events of gallstone formation. Previous studies that compared the calcium salt contents of cholesterol and p