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Cholesterol and phospholipids in membranes: The hydrogen bonding problem

✍ Scribed by Anil K. Lala

Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
277 KB
Volume
20
Category
Article
ISSN
0020-7608

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✦ Synopsis

Abstract

Cholesterol and phospholipids are major components of biological membranes. The role of cholesterol in membranes is not metabolic and is known to be a regulator of membrane fluidity which in turn regulates various biological phenomena. We have studied the nature of cholesterol and phospholipid interaction in artificial membranes using ^13^C NMR spectroscopy. This involved preparation of phospholipids specifically labeled with ^13^C in the ester carbonyl group. Though the chemical shift data did not provide very useful information the T~1~ and T~2~ measurements indicated that previously proposed H bonding between the ester carbonyl group and hydroxyl group of cholesterol seems unprobable.

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