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Cholesterol and anionic phospholipids increase the binding of amyloidogenic transthyretin to lipid membranes

โœ Scribed by Xu Hou; Adam Mechler; Lisandra L. Martin; Marie-Isabel Aguilar; David H. Small


Book ID
116274549
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
616 KB
Volume
1778
Category
Article
ISSN
0005-2736

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Systemic deposition of transthyretin (TTR) amyloid fibrils is always observed in familial amyloidotic polyneuropathy, senile systemic amyloidosis and familial amyloidotic cardiomyopathy patients. Destabilization of the molecule leads to a cascade of events which result in fibril formation. The desta