Cholestasis and biliary excretion of lipids induced by ethinylestradiol in rats fed polyunsaturated oils
✍ Scribed by Mariane Lutz; Patricia Carreño; Iris González
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 427 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0955-2863
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✦ Synopsis
Pharmacologic doses of ethinylestradiol are known to cause intrahepatic cholestasis in the rat. This is associated with a decrease in liver plasma membranes fluidity and a modification of the activity of membrane-bound enzymes related to bile flow. The intake of a diet containing highly polyunsaturated fats could modify the effects of estrogen, by increasing membranes fluidity due to their incorporation into structural phospholipids. To evaluate this action, rats were fed semipurified diets containing 17% corn (Zea rnais) oil or rose hip (Rosa moschata Mill) seed oil during 20 days. Following this period, a group of animals were injected with ethinylestradiol during 5 days, while a control group and a pair fed group were included. Cholestasis was similar between corn and rose hip oils fed to ethinylestradioltreated rats. The biliary excretion of cholesterol was higher in rose hip oil compared to corn oil-fed control rats. Biliary cholesterol/phospholipids ratio decreased in estrogen-treated rats compared to control animals. Our results show that the intake of highly polyunsaturated fatty acids did not modify the expected action of ethinylestradiol in rats.