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Cholera Toxin Inhibits the T-Cell Antigen Receptor-Mediated Increases in Inositol Trisphosphate and Cytoplasmic Free Calcium

โœ Scribed by John B. Imboden, Dolores M. Shoback, Gregory Pattison and John D. Stobo


Book ID
123633001
Publisher
National Academy of Sciences
Year
1986
Tongue
English
Weight
873 KB
Volume
83
Category
Article
ISSN
0027-8424

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Cholera toxin inhibits the increase in c
โœ Jacques Nunes; Marcello Bagnasco; Marc Lopez; Daniel Olive; Claude Mawas ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 556 KB

We investigated the action of cholera toxin on the intracellular ionized calcium [Ca2+]i increase induced by anti-CD2 and anti-CD3 monoclonal antibodies in the leukemic human T-cell line Jurkat. Cholera toxin inhibits in a dose-dependent manner these two pathways of human T-lymphocyte activation but