Cholecystokinin peptides in cerebrospinal fluid: a pilot study in hypothyroid patients

✍ Scribed by Tove Gunnarsson; Stefan Sjöberg; Mats Eriksson; Conny Nordin

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 80 KB
• Volume: 14
• Category: Article
• ISSN: 0885-6222
• DOI: 10.1002/(sici)1099-1077(199903)14:2<113::aid-hup76>3.0.co;2-a

✦ Synopsis

The cholecystokinin tetrapeptide (CCK-4) and the sulphated octapeptide (CCK-8) were measured in cerebrospinal ¯uid obtained from nine hypothyroid patients before and during L-thyroxine treatment. Before treatment, CCK-4 and CCK-8S correlated negatively with S-TSH, whereas CCK-8S also showed a positive correlation with S-T3. During treatment, S-T4 correlated negatively with CCK-8S. CSF collection time was signi®cantly shorter during treatment than prior to treatment for the ®rst (0±6 ml) CSF fraction. On taking CSF collection time into account, the levels of both CCK-4 and CCK-8S in the ®rst CSF fraction were signi®cantly increased during medication. Our results are consistent with an impact of the hypothyroid disorder and L-thyroxine treatment on the disposition of CCK compounds in CSF. This might be due to an altered CSF circulation, but other mechanisms (e.g. metabolism or elimination) cannot be ruled out.