Cholecystokinin antagonists. Synthesis and biological evaluation of 3-substituted benzolactams
โ Scribed by Parsons, W. H.; Patchett, A. A.; Holloway, M. K.; Smith, G. M.; Davidson, J. L.; Lotti, V. J.; Chang, R. S. L.
- Book ID
- 120040027
- Publisher
- American Chemical Society
- Year
- 1989
- Tongue
- English
- Weight
- 640 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0022-2623
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The synthesis of a series of RGD mimetics is described. All compounds have a 1.4:3.6diarthydrohexitol core, a variable linker to a guanidino group, and a serine ether to mimic the carboxylic acid. Two types of linkers were combined with 1.4:3.6-dianhydro-D-sorbitol ( I -4) and with 1,4:3,6-dianhydro